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Napierh Stephen... Read more
Published on: 2021-01-22
Source: JOURNAL OF CLINICAL RESEARCH & BIOETHICS - table of contents
Background: Therapeutic drug monitoring (TDM) involves the measurement of serum drug concentrations to optimize pharmacotherapy. Traditionally, blood pressure measurements alone, and not TDM, have been used to evaluate the antihypertensive drug response. However, approximately 50% of hypertensive patients treated with lifestyle changes and antihypertensive drugs fail to achieve blood pressure... Read more
Published on: 2021-01-22
Source: THERAPEUTIC DRUG MONITORING - most viewed articles
Background: Over the past decade, numerous obesity-specific pharmacokinetic (PK) models and dosage regimens have been developed. However, it is unclear whether vancomycin PKs differ between obese and other patients after accounting for weight, age, and kidney function. In this study, the authors investigated whether using obesity-specific population PK models for... Read more
Published on: 2021-01-22
Source: THERAPEUTIC DRUG MONITORING - most viewed articles
No abstract available... Read more
Published on: 2021-01-22
Source: THERAPEUTIC DRUG MONITORING - latest articles
No abstract available... Read more
Published on: 2021-01-22
Source: THERAPEUTIC DRUG MONITORING - latest articles
Background: Tuberculosis (TB) remains one of the most important infectious diseases. Population pharmacokinetic (pop-PK) models are widely used to individualize dosing regimens of several antibiotics, but their application in anti-TB drug studies is scant. The aim of this study was to provide an insight regarding the status of pop-PK for... Read more
Published on: 2021-01-22
Source: THERAPEUTIC DRUG MONITORING - latest articles
Background: The use of therapeutic drug monitoring (TDM) to guide treatment with long-acting injectable (LAI) antipsychotics, which are increasingly prescribed, remains a matter of debate. The aim of this review was to provide a practical framework for the integration of TDM when switching from an oral formulation to the LAI... Read more
Published on: 2021-01-22
Source: THERAPEUTIC DRUG MONITORING - latest articles
Background: Therapeutic drug monitoring (TDM) involves the measurement of serum drug concentrations to optimize pharmacotherapy. Traditionally, blood pressure measurements alone, and not TDM, have been used to evaluate the antihypertensive drug response. However, approximately 50% of hypertensive patients treated with lifestyle changes and antihypertensive drugs fail to achieve blood pressure... Read more
Published on: 2021-01-22
Source: THERAPEUTIC DRUG MONITORING - latest articles
Background: Although the efficacy of lopinavir/ritonavir has not been proven, it has been proposed as an off-label treatment for COVID-19. Previously, it has been reported that the plasma concentrations of lopinavir significantly increase in inflammatory settings. As COVID-19 may be associated with major inflammation, assessing the plasma concentrations and safety... Read more
Published on: 2021-01-22
Source: THERAPEUTIC DRUG MONITORING - latest articles
Purpose: Oseltamivir is indicated for the treatment and prophylaxis of influenza infections. Achieving therapeutic concentrations EARLY in the course of the infection impacts greatly on the magnitude of benefit. Oseltamivir is renally cleared and dose reductions are advised for patients with renal impairment. The purpose of this review was to... Read more
Published on: 2021-01-22
Source: THERAPEUTIC DRUG MONITORING - latest articles
Background: With the development of industrialization in human society, ambient pollutants are becoming more harmful to human health. Epidemiological and toxicological studies indicate that a close relationship exists between particulate matter with a diameter ≤2.5 µm (PM2.5) and neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). To... Read more
Published on: 2021-01-22
Source: THERAPEUTIC DRUG MONITORING - latest articles
Abstract: In the U.S., an opioid overdose crisis has emerged, attributable to over-prescription of opioid analgesics, driven by aggressive marketing by pharmaceutical companies, followed by surging heroin overdose deaths, and more recently, by the high mortality rates predominately because of illicitly manufactured fentanyl and analogs of fentanyl. In Europe, the... Read more
Published on: 2021-01-22
Source: THERAPEUTIC DRUG MONITORING - latest articles

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